hemH

hemH
168

coproporphyrin ferrochelatase

Locus
BSU_10130
Molecular weight
35.19 kDa
Isoelectric point
4.62
Protein length
310 aaSequenceBlast
Gene length
933 bpSequenceBlast
Function
biosynthesis of heme
Product
coproporphyrin ferrochelatase
Essential
no
E.C.
4.99.1.1
Synonyms
hemH, hemF, cpfC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0276 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,087,250 → 1,088,182
The protein
Catalyzed reaction/ biological activity
coproporphyrin --> coproheme PubMed
2 H+ + heme b --> Fe2+ + protoporphyrin IX (according to UniProt)
Protein family
ferrochelatase family (with YlnF, according to UniProt)
Structure
2HK6 (PDB) (complex with iron) PubMed
1AK1 (PDB) PubMed
P32396 (AlphaFold)
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
hemE-hemH-hemY
Description
PubMed
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hemE→hemY

2025-03-28 21:22:41

ghost

111

cc3badb89ccb30b0e5bcbdd78cda19adf9729720

53F55E33273DE40E70DE56EF56FA66E9935433B9

Biological materials
Mutant
BKE10130 (ΔhemH::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACTGTTTACACCCTCTTTA,  downstream forward: _UP4_GGACGTTAAAGAAGGCGATG
BKK10130 (ΔhemH::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACTGTTTACACCCTCTTTA,  downstream forward: _UP4_GGACGTTAAAGAAGGCGATG
References
Reviews
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Original Publications
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E4C588EC93132CCBE4F40559F8A480A66A2D82D7

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Time of last update: 2025-04-06 22:59:25

Author of last update: Jstuelk