Difference between revisions of "TnrA"
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=Labs working on this gene/protein= | =Labs working on this gene/protein= | ||
− | + | * [[Susan Fisher]], Boston, USA [http://www.bumc.bu.edu/microbiology/research/susan-h-fisher-phd/ homepage] | |
− | [[Susan Fisher]], Boston, USA [http://www.bumc.bu.edu/microbiology/research/susan-h-fisher-phd/ homepage] | + | * [[Maria Schumacher]], Durham, NC, USA [http://www.dukeschumacherlab.com/index.html homepage] |
=Your additional remarks= | =Your additional remarks= |
Revision as of 12:37, 5 March 2015
- Description: transcriptional pleiotropic regulator (MerR family) involved in global nitrogen regulation
Gene name | tnrA |
Synonyms | scgR |
Essential | no |
Product | transcription activator/ repressor (MerR family) |
Function | regulation of nitrogen assimilation |
Gene expression levels in SubtiExpress: tnrA | |
Interactions involving this protein in SubtInteract: TnrA | |
Metabolic function and regulation of this protein in SubtiPathways: tnrA | |
MW, pI | 12 kDa, 10.235 |
Gene length, protein length | 330 bp, 110 aa |
Immediate neighbours | mgtE, ykzB |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids, glutamate metabolism, transcription factors and their control, regulators of core metabolism
This gene is a member of the following regulons
The TnrA regulon
The gene
Basic information
- Locus tag: BSU13310
Phenotypes of a mutant
Database entries
- BsubCyc: BSU13310
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: MerR family
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- K(D) value for the binding site in the tnrA promoter region: 55 nM PubMed
- Domains:
- Modification:
- Cofactor(s):
- Localization: membrane-associated via NrgA-NrgB under conditions of poor nitrogen supply PubMed
Database entries
- BsubCyc: BSU13310
- UniProt: Q45666
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: tnrA (according to DBTBS)
- Regulation:
- Additional information:
Biological materials
- Mutant: GP252 (in frame deletion), available in the Stülke lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody: available in the Karl Forchhammer lab
Labs working on this gene/protein
- Susan Fisher, Boston, USA homepage
- Maria Schumacher, Durham, NC, USA homepage
Your additional remarks
References
Reviews
The TnrA regulon
Control of TnrA activity by the trigger enzyme GlnA
Other original publications