ppaC

ppaC
168

inorganic pyrophosphatase

Locus
BSU_40550
Molecular weight
33.83 kDa
Isoelectric point
4.51
Protein length
309 aaSequenceBlast
Gene length
930 bpSequenceBlast
Function
recovery of phosphate ions from pyrophosphate
Product
inorganic pyrophosphatase
Essential
yes
E.C.
3.6.1.1
Synonyms
ppaC, yybQ
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1227 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
4,168,204 4,169,133
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
diphosphate + H2O --> H+ + 2 phosphate (according to UniProt)
Protein family
PPase class C family (single member, according to UniProt)
Domains
DHH-DHHA1 domain
Cofactors
Mn2+ PubMed
Structure
2HAW (PDB) (complex with substrate analogue p-nitrophosphate), 1WPM (PDB) PubMed
P37487 (AlphaFold)
Modification
S-cysteinylation after diamide stress (C158) PubMed
Cys158 is S-bacillithiolated by NaOCl stress in B. subtilis and other Bacillus species PubMed PubMed
Localization
cytoplasm (according to Swiss-Prot)
Additional information
belongs to the 100 most abundant proteins PubMed
Expression and Regulation
Operons
Genes
ppaC
Description
PubMed
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ppaC

2025-03-16 17:03:47

ghost

128

fcd43ca793c3486a825abbc00181018ac52e3ac8

258CFB2719165018458171A538329ED5E6856B8F

Biological materials
Mutant
MGNA-B837 (yybQ::erm), available at the NBRP B. subtilis, Japan
References
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AE44787B3EB8EF5811B5C447BE2012EC36547B0A

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Time of last update: 2025-04-05 12:12:47

Author of last update: Jstuelk