flhB

flhB
168

part of the flagellar type III export apparatus (flagellar Type III secretion system), part of the CORE complex required for flagellum and nanotube assembly

Locus
BSU_16380
Molecular weight
40.94 kDa
Isoelectric point
9.77
Protein length
360 aaSequenceBlast
Gene length
1083 bpSequenceBlast
Function
flagellum and nanotube assembly
Product
part of the type III CORE export apparatus
Essential
no
Synonyms
flhB
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1377 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,706,599  1,707,681
Phenotypes of a mutant
no secretion of FlgM, permanent inhibition of SigD PubMed
deficient in both nanotube production and the associated intercellular molecular trafficking PubMed
defective in Swarming motility PubMed
Additional information
the fhlB gene is often inactivated during adaptation to plants PubMed
The protein
Protein family
Type III secretion exporter family (single member, according to UniProt)
Structure
6S3L (PDB) (from Vibrio mimicus, 37% identity) PubMed
P35538 (AlphaFold)
Localization
cell membrane, 4 transmembrane helices PubMed
Expression and Regulation
Operons
Genes
ylxF-fliK-flgD-flgE-swrD-fliL-fliM-fliY-cheY-fliO-fliP-fliQ-fliR-flhB-flhA-flhF-flhG-cheB-cheA-cheW-cheC-cheD-sigD-swrB
Description
PubMed
Regulation
see fla-che operon
Regulatory mechanism
Spo0A: repression, in spo0A regulon
CodY: repression, in codY regulon
DegU: repression, in degU regulon
SwrA: activation, in swrA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigD: sigma factor, PubMed, in sigD regulon
Open in new tab

ylxF→swrB

2025-04-04 21:21:07

Jstuelk

170

EECFE9022742ECC57D9BBA5CE7DB7A4D1BFD42A8

0535E3D13CBD000A94D62050515BF8D1D5E3F011

Genes
flgB-flgC-fliE-fliF-fliG-fliH-fliI-fliJ-ylxF-fliK-flgD-flgE-swrD-fliL-fliM-fliY-cheY-fliO-fliP-fliQ-fliR-flhB-flhA-flhF-flhG-cheB-cheA-cheW-cheC-cheD-sigD-swrB
Description
PubMed
Regulation
expression during spore germination is strongly reduced under conditions of osmotic stress PubMed
Regulatory mechanism
Spo0A: repression, in spo0A regulon
SwrA: activation, in swrA regulon
CodY: repression, in codY regulon
DegU: repression, in degU regulon
SinR: transcription elongation, binding of the SinR-SlrR heteromer to sites within fliE and fliI results in inhibition of transcription elongation PubMed, in sinR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigD: sigma factor, PubMed, in sigD regulon
Open in new tab

flgB→swrB

2025-04-03 01:56:48

Jstuelk

173

024d59ae468aa14568753f57122b789c39ed6c06

4D920B925DA071AE7390E022B9AB625E40B7B2AC

Biological materials
Mutant
BKE16380 (flhB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CTGCAGGTCAACTCTAAGCT,  downstream forward: _UP4_TGAATTTTTCGATTTAAAAG
BKK16380 (flhB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CTGCAGGTCAACTCTAAGCT,  downstream forward: _UP4_TGAATTTTTCGATTTAAAAG
References
Reviews
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Original Publications
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68DB2871A88535714C84FE86006AB54CEB6F0EAD

Page visits: 3766

Time of last update: 2025-04-10 08:13:51

Author of last update: Jstuelk