phoR
168

two-component sensor kinase, regulation of phosphate metabolism

Locus

BSU_29100

Molecular weight

64.95 kDa

Isoelectric point

5.96

Protein length

579 aaSequenceBlast

Gene length

1740 bpSequenceBlast

Function

regulation of phosphate metabolism

Product

two-component sensor kinase

Essential

Synonyms

phoR

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

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Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5002 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

2,976,068 → 2,977,807

The protein

Catalyzed reaction/ biological activity

autophosphorylation, phosphorylation of PhoP

ATP + protein L-histidine --> ADP + protein N-phospho-L-histidine (according to UniProt)

Domains

two transmembrane segments

PAS domain, for binding of an intermediate of wall teichoic acid biosynthesis (lipid V composed of poly(glycerol phosphate)) PubMed

Histidine kinase domain (aa 357-575) (according to UniProt)

Structure

3CWF (PDB) (extracellular domain) PubMed

P23545 (AlphaFold)

Modification

autophosphorylation on a His residue in response to the the availability of an intermediate of wall teichoic acid bioynthesis, autophosphorylation is prevented by binding of this intermediate to the intracellular PAS domain of PhoR PubMed

Effectors of protein activity

activity is inhibited by binding of an intermediate of wall teichoic acid biosynthesis (lipid V composed of poly(glycerol phosphate) to the intracellular PAS domain of PhoR PubMed

the kinase activity is activated by an intermediate in the WTA biosynthetic pathway (product of TagA or TagB) PubMed

Paralogous protein(s)

WalK, ResE

Localization

cell membrane (according to UniProt)

Expression and Regulation

Operons

Genes

phoP-phoR

Description

PubMed

Regulation