Difference between revisions of "Main Page"
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| − | <big>'''Paper of the month: | + | <big>'''Paper of the month: February 2015'''</big> |
| − | * | + | * To proliferate efficiently, cells must co-ordinate [[cell division]] with [[DNA condensation/ segregation|chromosome segregation]]. In ''B. subtilis'', the nucleoid occlusion protein [[Noc]] binds to specific DNA sequences scattered around the chromosome and helps to protect genomic integrity by coupling the initiation of division to the progression of chromosome replication and segregation. However, how it inhibits division has remained unclear. Now, [http://www.ncbi.nlm.nih.gov/pubmed/25568309 Adams et al.] from the lab of [[Jeff Errington]] demonstrate that [[Noc]] associates with the cell membrane via an N-terminal amphipathic helix. Importantly, the membrane-binding affinity of this helix is weak and requires the assembly of nucleoprotein complexes, thus establishing a mechanism for DNA-dependent activation of [[Noc]]. Furthermore, division inhibition by [[Noc]] requires recruitment of [[Noc]] binding site DNA to the cell membrane and is dependent on its ability to bind DNA and membrane simultaneously. The results suggest a simple model in which the formation of large membrane-associated nucleoprotein complexes physically occludes assembly of the [[divisome|division machinery]]. |
| − | * '''Relevant ''Subti''Wiki pages:''' [[ | + | * '''Relevant ''Subti''Wiki pages:''' [[Noc]], [[Jeff Errington]], [[cell division]], [[DNA condensation/ segregation|chromosome segregation]] |
| − | <pubmed> | + | <pubmed>25568309</pubmed> |
* [[Previous papers of the month]] | * [[Previous papers of the month]] | ||
Revision as of 16:36, 4 February 2015
Welcome to SubtiWiki! - Bacillus subtilis annotation the "wiki" way!
Contact: General Microbiology, University of Göttingen, send mail
Upcoming events:
- The BACELL meeting 2015, organized by Leendert Hamoen will take place from April 14 to 15 in Amsterdam, The Netherlands. Website, Contact
- The International Conference on Metabolic Engineering, organized by Ivan Mijakovic and Leendert Hamoen will take place from April 16 to 17 in Amsterdam, The Netherlands. Website, Contact
- The 8th International Conference on Gram-positive Microorganisms (18th International Conference on Bacilli) in Montecatini Terme, organized by Marta Perego, Jim Hoch, and Hendrik Szurmant will take place from June 21 to 25. Conference website
- Past conferences
New: Subtiwiki is now on Facebook - please give it a +1!
Now online: A new description of SubtiWiki and its acompanying modules in the 2014 Database issue of Nucleic Acids Research
Paper of the month: February 2015
- To proliferate efficiently, cells must co-ordinate cell division with chromosome segregation. In B. subtilis, the nucleoid occlusion protein Noc binds to specific DNA sequences scattered around the chromosome and helps to protect genomic integrity by coupling the initiation of division to the progression of chromosome replication and segregation. However, how it inhibits division has remained unclear. Now, Adams et al. from the lab of Jeff Errington demonstrate that Noc associates with the cell membrane via an N-terminal amphipathic helix. Importantly, the membrane-binding affinity of this helix is weak and requires the assembly of nucleoprotein complexes, thus establishing a mechanism for DNA-dependent activation of Noc. Furthermore, division inhibition by Noc requires recruitment of Noc binding site DNA to the cell membrane and is dependent on its ability to bind DNA and membrane simultaneously. The results suggest a simple model in which the formation of large membrane-associated nucleoprotein complexes physically occludes assembly of the division machinery.
- Relevant SubtiWiki pages: Noc, Jeff Errington, cell division, chromosome segregation
New procedure for account creation:
- Due to massive spam attacks, we had to change our policy for the creation of accounts. If you want to create an account, just send me a mail. We will create the account for you as quickly as possible, then you can change your password. This does not affect existing accounts, which remain active.
- Please remember that all members of the Bacillus community are invited to create accounts and to contribute to SubtiWiki!
News in SubtiWiki:
- August 2014: The first mobile application for SubtiWiki is now available for users of Android phones: Go for SubtiWiki in Google Play! IPhone users, please be patient! You will be served next! Click here to install!
- April 2013: SubtiWiki uses a new, faster Mediawiki platform! The times for page access are significantly reduced. Enjoy!
- March 2013: updated Excel files that map all genes to categories and regulons as well as the general updated identity mapping of all genes were uploaded.
- October 2012: the essential genes have been categorized
- September 2012: 300 mutant strains available at the BGSC were added to the corresponding gene pages
- August 2012: SubtiExpress, the new compagnon of SubtiWiki devoted to gene expression is online! Try it out!
- April 2012: Links for expression data under 104 different conditions (based on Nicolas et al., 2012) have been added to the expression section of the individual gene pages
- April 2011: SubtInteract, a presentation of protein-protein interactions in B. subtilis, is online!
- December 2010: SubtiCellPublisher allows the conversion of CellDesigner diagrams to navigatable presentations in the style of SubtiPathways
| Genes (examples) | Additional pages |
| spo0A | SubtiPathways |
| glnA | SubtInteract |
| rny | SubtiExpress |
| psdA | Regulons |
| pckA | methods |
| dnaA | metabolism |
| rnpA | categories |
| sigB | genome-wide analyses |
| ptkA | list of plasmids |
| mreC | labs working on Bacillus |
| ccpA | the people behind SubtiWiki |
| sr1 | template |
Publications describing SubtiWiki and SubtiPathways:
