mrnC

mrnC
168

RNase Mini-III

Locus
BSU_00950
Molecular weight
16.09 kDa
Isoelectric point
9.15
Protein length
143 aaSequenceBlast
Gene length
432 bpSequenceBlast
Function
maturation of 23S rRNA
Product
RNase Mini-III
Essential
no
Synonyms
mrnC, yazC
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

List of homologs in different organisms, belongs to COG1939 (Galperin et al., 2021)

This gene is a member of the following regulons

SigA regulon, T-box

Gene
Coordinates
114,854  115,285
The protein
Protein family
MrnC RNase family (single member, according to UniProt)
Structure
4OUN (PDB) PubMed
O31418 (AlphaFold)
Effectors of protein activity
RplC binding to the precursor 23S rRNA stimulates MrnC activity PubMed
Expression and Regulation
Operons
Genes
gltX-cysE-cysS-mrnC-yacO-rae1
Description
PubMed
Regulation
expression transiently increases in the forespore PubMed
the T-box RNA is degraded by RNase Y PubMed
Regulatory mechanism
T-box: RNA switch, overlaps a transcription terminator upstream of cysE, in T-box
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

gltX→rae1

2025-04-04 01:30:11

Jstuelk

96

9ab774439b3983729fe5811aeaf44f4bc16c609f

BCC6FA512C81F405B92E34AE44A52F949D245F3D

Biological materials
Mutant
MGNA-B883 (yazC::erm), available at the NBRP B. subtilis, Japan
BKE00950 (mrnC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TATCGTATCAAATTCAAGCA,  downstream forward: _UP4_TTCGGGACGTCAGGGAGGAA
BKK00950 (mrnC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TATCGTATCAAATTCAAGCA,  downstream forward: _UP4_TTCGGGACGTCAGGGAGGAA
Labs working on this gene/protein
Ciaran Condon, IBPC, Paris, France Homepage
David Bechhofer, Mount Sinai School, New York, USA Laboratories and Programs/Bechhofer Laboratory?citype=Physician&ciid=Bechhofer David H 1255565 Homepage
References
Loading

031FDF8443A8A4D5B042B7591EBE2E6C74F07702

Page visits: 5434

Time of last update: 2025-04-06 14:04:43

Author of last update: Jstuelk