fabL

fabL
168

enoyl-acyl carrier protein reductase

Locus
BSU_08650
Molecular weight
27.03 kDa
Isoelectric point
5.97
Protein length
250 aaSequenceBlast
Gene length
753 bpSequenceBlast
Function
fatty acid biosynthesis
Product
enoyl-acyl carrier protein reductase
Essential
no
Synonyms
fabL, yfhR, ygaA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1028 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
937,079  937,831
The protein
Catalyzed reaction/ biological activity
2,3-saturated acyl-[ACP] + NADP+ --> (2E)-enoyl-[ACP] + H+ + NADPH (according to UniProt)
Protein family
Short-chain dehydrogenases/reductases (SDR) family (according to UniProt)
Structure
3OIC (PDB) PubMed
P71079 (AlphaFold)
Paralogous protein(s)
FabI, one of the two proteins has to be present for viability PubMed
YcdF, (31.6%)
YhdF, (30.1%)
YkvO, (31,8%)
Expression and Regulation
Operons
Genes
fabL-sspE
Description
PubMed
Regulation
repressed by casamino acids PubMed
Regulatory mechanism
SpoVT: repression, in spoVT regulon
YfhP: repression, in yfhP regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigG: sigma factor, PubMed, in sigG regulon
Open in new tab

fabL→sspE

2025-04-03 07:05:17

ghost

106

67265ff3bb89564e24e307e1cd5eb4bb4dbff57c

9C9F76530F9E01DE8E0DFAA748E25E67C55A5D59

Genes
mutY-fabL-sspE
Description
PubMed
Regulation
expression is constitutive throughout growth PubMed
Regulatory mechanism
YfhP: repression, in yfhP regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigG: sigma factor, PubMed, in sigG regulon
Open in new tab

mutY→sspE

2025-04-02 07:34:58

ghost

122

3a7a008cdfb01ec3e3352da847749371e7eede7c

C3DBF827F212448AA1AC6115B8D2A94E11E4693A

Biological materials
Mutant
MGNA-C324 (yfhR::erm), available at the NBRP B. subtilis, Japan
BKE08650 (fabL::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTTTCCTCATCTCCTTG,  downstream forward: _UP4_TAAAAATTTTTAAAAAAGAG
BKK08650 (fabL::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTTTCCTCATCTCCTTG,  downstream forward: _UP4_TAAAAATTTTTAAAAAAGAG
References
Reviews
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Original Publications
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5964B6E817260DA7937796DDFA753A665A04D650

Page visits: 5694

Time of last update: 2025-04-11 04:15:46

Author of last update: Jstuelk