ypqP
168

C-terminal part of the split gene spsM (together with yodU), legionaminic acid synthesis, in B. subtilis 168 the gene is disrupted by the SP-beta prophage

Locus

BSU_21670

Protein length

202 aaSequenceBlast

Gene length

606 bpSequenceBlast

Function

legionaminic acid synthesis

Product

UDP-NAcGlcA inverting 4,6-dehydratase (C-terminal part)

Essential

Synonyms

ypqP, spsM

Outlinks

BsubCyc SubtiList Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

This gene is a member of the following regulons

Gene

Coordinates

2,286,448 → 2,287,053

Phenotypes of a mutant

the ypqP mutant of PY79 has a less hydrophobic spore surface PubMed

The protein

Catalyzed reaction/ biological activity

SpsM catalyzes the C-4/C-6 dehydration of the UDP-GlcNAc to produce UDP-4-keto-6-deoxy-GlcNAc, this is the first reaction of the legionaminic acid biosynthesis pathway PubMed

required for spore crust assembly, legionaminic acid synthesis PubMed

Domains

SpsM: Polysacc_synt_2 domain (Pfam accession number, PF02719) in the 18–296-aa region PubMed

Structure

6BWC (PDB) (from B. thuringiensis, 39% identity) PubMed

Paralogous protein(s)

EpsC, (for SpsM)

Expression and Regulation

Operons

Genes

sprA-ypqP

Description