pyrF

pyrF
168

orotidine 5-phosphate decarboxylase

Locus
BSU_15550
Molecular weight
25.84 kDa
Isoelectric point
5.84
Protein length
239 aaSequenceBlast
Gene length
720 bpSequenceBlast
Function
pyrimidine biosynthesis
Product
orotidine-5-phosphate decarboxylase
Essential
no
E.C.
4.1.1.23
Synonyms
pyrF
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0284 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,628,622  1,629,341
Phenotypes of a mutant
poor growth PubMed
non-transformable PubMed
The protein
Catalyzed reaction/ biological activity
H+ + orotidine 5'-phosphate --> CO2 + UMP (according to UniProt)
Protein family
OMP decarboxylase family (single member, according to UniProt)
Structure
1DBT (PDB)
P25971 (AlphaFold)
Expression and Regulation
Operons
Genes
pyrR-pyrP-pyrB-pyrC-pyrAA-pyrAB-pyrK-pyrD-pyrF-pyrE
Description
PubMed
Regulation
induced in the absence of uridine nucleotides (PyrR) PubMed
Regulatory mechanism
PyrR: termination, via RNA switch, in pyrR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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pyrR→pyrE

2025-03-26 16:59:11

ghost

111

3b978222b0b6a5230a2e7701ac35d1e35cc85307

0A8FD5CB6489EDD8CB2074130B763DCAC1F24654

Biological materials
Mutant
BKE15550 (pyrF::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AAGTGTTTCTTCAGCTGACG,  downstream forward: _UP4_GCCTATAAGGCTGTCAGACT
BKK15550 (pyrF::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AAGTGTTTCTTCAGCTGACG,  downstream forward: _UP4_GCCTATAAGGCTGTCAGACT
References
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Time of last update: 2025-04-04 10:44:28

Author of last update: Melvin.boenninger