liaI
168

resistance against oxidative stress and cell wall antibiotics, membrane anchor for LiaH, secondary bacitracin resistance determinant

Locus

BSU_33130

Molecular weight

13.24 kDa

Isoelectric point

9.3

Protein length

126 aaSequenceBlast

Gene length

381 bpSequenceBlast

Function

resistance against oxidative stress and cell wall antibiotics

Product

membrane anchor for LiaH

Essential

Synonyms

liaI, yvqI

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

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Categories containing this gene/protein

List of homologs in different organisms

This gene is a member of the following regulons

Gene

Coordinates

3,398,550 → 3,398,930

The protein

Structure

O32202 (AlphaFold)

Localization

cell membrane PubMed

forms highly dynamic membrane-associated foci under non-inducing conditions PubMed

co-localizes with LiaH in distinct static spots at the cytoplasma membrane under stress conditions PubMed

Expression and Regulation

Operons

Genes

liaI-liaH

Description

PubMed

Regulation

induced by bacitracin and rhamnolipids, induction requires high bacitracin concentrations (LiaR) PubMed

Regulatory mechanism

LiaR: activation, PubMed, in liaR regulon

Sigma factors

SigA: sigma factor, PubMed, in sigA regulon

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Genes

liaI-liaH-liaG-liaF-liaS-liaR

Description

PubMed

Regulation

''liaG'': constitutive

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Biological materials

Mutant

MGNA-B040 (yvqI::erm), available at the NBRP B. subtilis, Japan

1A980 ( liaI::erm), PubMed, available at BGSC

BKE33130 (ΔliaI::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGCAGATCCTCCTTTCGT, downstream forward: _UP4_TAATATCAATATATTAGGAG

BKK33130 (ΔliaI::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGCAGATCCTCCTTTCGT, downstream forward: _UP4_TAATATCAATATATTAGGAG

References

Reviews

Original Publications

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Time of last update: 2025-04-14 07:36:33

Author of last update: Jstuelk

liaI 168

liaI
168