sipS

sipS
168

signal peptidase I

Locus
BSU_23310
Molecular weight
20.90 kDa
Isoelectric point
9.72
Protein length
184 aaSequenceBlast
Gene length
555 bpSequenceBlast
Function
protein secretion
Product
signal peptidase I
Essential
no
E.C.
3.4.21.89
Synonyms
sipS
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0681 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,432,316 → 2,432,870
Phenotypes of a mutant
a ''sipS sipT'' double mutant is not viable PubMed
The protein
Catalyzed reaction/ biological activity
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to UniProt)
intra-membrane cleavage and thus inactivation of RsiV between A66 and M67 PubMed
Protein family
peptidase S26 family (according to UniProt)
Structure
4NV4 (PDB) (from Bacillus anthracis, 40% identity)
P28628 (AlphaFold)
Paralogous protein(s)
SipU, SipV, SipT
Localization
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
ypzJ-sipS
Description
PubMed
Open in new tab

ypzJ→sipS

2025-03-21 20:10:55

Jstuelk

84

b52e82e792325bf0ec46e075409345488df6c4f2

B44EE202E5D62B1BD6EA66C9CFEDE1091C079957

Genes
sipS
Description
PubMed
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

sipS

2025-04-06 01:03:26

ghost

73

37091711b1d398da9c5601374f168f6fd2f66dee

E5F88F88D8A39A28ADFFD1AF448ABD624DB35145

Biological materials
Mutant
BKE23310 (ΔsipS::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAACTGATTTCCTCCAATAA,  downstream forward: _UP4_TAGGATCAAGCAGCTTCCCA
BKK23310 (ΔsipS::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAACTGATTTCCTCCAATAA,  downstream forward: _UP4_TAGGATCAAGCAGCTTCCCA
Labs working on this gene/protein
Jan Maarten van Dijl, Groningen, Netherlands
References
Reviews
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Original Publications
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CDC6971F39F3EEAAE912CB1402EE1BD64D5A12A0

Page visits: 3478

Time of last update: 2025-04-10 14:35:14

Author of last update: Jstuelk