mntR

mntR
168

transcriptional regulator, controls manganese import and efflux

Locus
BSU_24520
Molecular weight
16.60 kDa
Isoelectric point
5.63
Protein length
142 aaSequenceBlast
Gene length
429 bpSequenceBlast
Function
regulation of manganese transport
Product
transcriptional regulator (DtxR family)
Essential
no
Synonyms
mntR, yqhN
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1321 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,543,440 → 2,543,868
Phenotypes of a mutant
inactivation of mntR reduces sporulation efficiency to 8.9% that of wild type cells PubMed
highly sensitive to Mn(II) intoxication PubMed, this can be suppressed by mutations that inactivate MntH PubMed
sensitive to iron intoxication due to loss of expression of mneP and mneS PubMed
more sensitive to H2O2 PubMed
The protein
Catalyzed reaction/ biological activity
dual regulatory protein, responds to heightened Mn(2+) availability by repressing the expression of uptake transporters and activating the expression of efflux proteins PubMed
Protein family
DtxR/MntR family (single member, according to UniProt)
Domains
HTH dtxR-type domain (aa 1-63) (according to UniProt)
Cofactors
Mn2+ acts as co-repressor/ co-activator (according to PubMed)
Structure
9C4D (PDB) complex with MntR bound to mneP upstream DNA fragment PubMed
2F5D (PDB) (complex with manganese) PubMed
2HYG (PDB) (apo-form)
P54512 (AlphaFold)
Effectors of protein activity
Mn2+ ions facilitate DNA binding and thus repression or activation of the genes of the MntR regulon PubMed
Expression and Regulation
Operons
Genes
mntR
Description
PubMed
Open in new tab

mntR

2025-04-01 15:13:12

Jstuelk

78

8c297ff8e026fc3f440b348f63f4f2d1cbc7719c

012134C3E767C579800BBBF24B32F57C6FC2ED29

Genes
lipM-mntR
Description
PubMed
Open in new tab

lipM->mntR

2025-03-31 23:42:39

Jstuelk

72

43142196e46b9630ee956a30cb1c43887eb0465a

68845A224A7971C2B25ADC30013D1BE3E2F7504C

Biological materials
Mutant
MGNA-C435 (yqhN::erm), available at the NBRP B. subtilis, Japan
BKE24520 (ΔmntR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCGAAACCCTCCCAAAAA,  downstream forward: _UP4_TAAAAAGGCGGTCTCGAAGG
BKK24520 (ΔmntR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCGAAACCCTCCCAAAAA,  downstream forward: _UP4_TAAAAAGGCGGTCTCGAAGG
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
Richard Brennan, Houston, Texas, USA Homepage
References
Reviews
Loading
Original Publications
Loading

FF34DC303E8A7C9FAA205A6C2924961963B14EB1

Page visits: 4476

Time of last update: 2025-04-13 05:52:54

Author of last update: Jstuelk