csaA
168

molecular chaperone involved in protein secretion

Locus

BSU_19040

Molecular weight

11.77 kDa

Isoelectric point

8.69

Protein length

110 aaSequenceBlast

Gene length

333 bpSequenceBlast

Function

protein secretion

Product

molecular chaperone

Essential

Synonyms

csaA

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

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Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0073 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

2,079,214 → 2,079,546

Phenotypes of a mutant

From unsuccessful trials to knock out the gene it was concluded that csaA apparently is essential. However, in a conditional mutant (Pspac-csaA), depletion of the gene product is not lethal. But secretion of some proteins including SdpC was reported to be affected unter such conditions.PubMed

The protein

Catalyzed reaction/ biological activity

Secretion associated chaperone. Assumed functional analogue of E. coli SecB

Protein family

FIG1 subfamily (according to Swiss-Prot)

Domains

tRNA-binding domain (aa 6-110) (accordinig to UniProt)

Structure

2NZO (PDB)

P37584 (AlphaFold)

Localization

cytoplasm PubMed