lysA

lysA
168

diaminopimelate decarboxylase

Locus
BSU_23380
Molecular weight
48.41 kDa
Isoelectric point
5.01
Protein length
439 aaSequenceBlast
Gene length
1317 bpSequenceBlast
Function
biosynthesis of lysine
Product
diaminopimelate decarboxylase
Essential
no
E.C.
4.1.1.20
Synonyms
lysA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0019 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,436,947 → 2,438,266
Phenotypes of a mutant
auxotrophic for lysine PubMed
reduced conjugation of ICEBs1 PubMed
The protein
Catalyzed reaction/ biological activity
H+ + meso-2,6-diaminopimelate --> CO2 + L-lysine (according to UniProt)
Protein family
Orn/Lys/Arg decarboxylase class-II family (single member, according to UniProt)
Cofactors
PLP (according to UniProt)
Structure
1HKW (PDB) (from Mycobacterium tuberculosis, 42% identity, 61% similarity) PubMed
P23630 (AlphaFold)
Expression and Regulation
Operons
Genes
spoVAA-spoVAB-spoVAC-spoVAD-spoVAEB-spoVAEA-spoVAF-lysA
Description
PubMed
Regulation
expressed late during sporulation in the forespore (SigG, SpoVT) PubMed
Regulatory mechanism
SpoVT: activation, PubMed, in spoVT regulon
Sigma factors
SigG: sigma factor, PubMed, in sigG regulon
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spoVAA→lysA

2025-04-25 20:53:11

Jstuelk

133

12fce0add6fb0abbed0128cd99d7be2c377e96d5

420F73950DA10EFCB3126E84B350E66BA95D34DD

Genes
lysA
Description
PubMed
Open in new tab

lysA

2025-03-15 07:07:13

Jstuelk

69

d86e94834f2dae2dfcf9d695bd0ee6e466117994

9CBEAB013175E6509E509C5928AC6BC3DC05F000

Biological materials
Mutant
1A615 ( lysA::erm), PubMed, available at BGSC
BKE23380 (ΔlysA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAATGTCATTCCCTCTTTCT,  downstream forward: _UP4_TAAAAGAAAGCGCCGATTTT
BKK23380 (ΔlysA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAATGTCATTCCCTCTTTCT,  downstream forward: _UP4_TAAAAGAAAGCGCCGATTTT
References
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02F1C926D200DE85C93A0ACEF23AD25FBD12B0BD

Page visits: 4452

Time of last update: 2025-04-21 23:40:16

Author of last update: Melvin.boenninger