mraY
168

phospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate), catalyzes the first commited membrane-bound step of bacterial peptidoglycan synthesis leading to the formation of lipid I

Locus

BSU_15190

Molecular weight

35.44 kDa

Isoelectric point

8.97

Protein length

324 aaSequenceBlast

Gene length

975 bpSequenceBlast

Function

peptidoglycan precursor biosynthesis

Product

phospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate)

Essential

yes

E.C.

2.7.8.13

Synonyms

mraY

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0472 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

1,587,926 1,588,900

Phenotypes of a mutant

essential PubMed

The protein

Catalyzed reaction/ biological activity

di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine --> Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + UMP (according to UniProt)

Protein family

glycosyltransferase 4 family (with TagO, according to UniProt)

Structure

5JNQ (PDB) PubMed

Q03521 (AlphaFold)

Localization

cell membrane (according to UniProt)

forms banded patterns along the length of the cell, this pattern formation depends on MreB PubMed

Expression and Regulation

Operons

Genes