yxdJ

yxdJ
168

two-component response regulator (OmpR family), regulation of the ABC transporter YxdL-YxdM in response to the cationic antimicrobial peptide, LL-37

Locus
BSU_39660
Molecular weight
26.45 kDa
Isoelectric point
4.94
Protein length
229 aaSequenceBlast
Gene length
690 bpSequenceBlast
Function
resistance against toxic peptides
Product
two-component response regulator (OmpR family)
Essential
no
Synonyms
yxdJ, apeR
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0745 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
4,072,284 → 4,072,973
The protein
Protein family
OmpR family of two-component response regulators
Domains
Response regulatory domain (aa 3-116) (according to UniProt)
Structure
5DCL (PDB) (NisR from Streptococcus agalactiae, 41% identity)
P42421 (AlphaFold)
Modification
phosphorylated by YxdK on an Asp residue
Expression and Regulation
Operons
Genes
yxdJ-yxdK
Description
PubMed
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yxdJ→yxdK

2025-04-01 00:15:25

ghost

69

c76296e9310bddd35358eaa89ad1a230129a405b

44273BFA6B2172951C5D6DC21EB86FC3F740762F

Biological materials
Mutant
MGNA-B702 (yxdJ::erm), available at the NBRP B. subtilis, Japan
BKE39660 (ΔyxdJ::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAACTGAACCACTCCCGTT,  downstream forward: _UP4_GGCTACCAGCTGAGGGCGCA
BKK39660 (ΔyxdJ::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAACTGAACCACTCCCGTT,  downstream forward: _UP4_GGCTACCAGCTGAGGGCGCA
References
Reviews
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Original Publications
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F3C5505E311E6DDABAFA87899F28CF6596CDBA63

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Time of last update: 2025-04-11 20:48:33

Author of last update: Jstuelk