yclJ

yclJ
168

two-component response regulator (OmpR family), active under anaerobic conditions

Locus
BSU_03750
Molecular weight
26.36 kDa
Isoelectric point
4.58
Protein length
227 aaSequenceBlast
Gene length
684 bpSequenceBlast
Function
unknown
Product
two-component response regulator (OmpR family)
Essential
no
Synonyms
yclJ
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0745 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
426,577  427,260
The protein
Protein family
OmpR family of two-component response regulators
Domains
Response regulatory domain (aa 2-115) (according to UniProt)
Structure
2OQR (PDB) (RegX3 from Mycobacterium tuberculosis, 42% identity) PubMed
P94413 (AlphaFold)
Modification
phosphorylated by YclK on an Asp residue
Effectors of protein activity
phosphorylation likely affects DNA-binding activity
Paralogous protein(s)
WalR, YkoG, PhoP
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
yclJ-yclK
Description
PubMed
Regulation
expressed under anaerobic conditions (ResD) PubMed
Regulatory mechanism
ResD: activation, PubMed, in resD regulon
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yclJ→yclK

2025-04-04 07:59:38

ghost

86

c8ce174a850d100d730c47471cd54e3718b10202

35D763A96FACAEA24FD2F2D86E1687EA9C120E8E

Biological materials
Mutant
MGNA-C007 (yclJ::erm), available at the NBRP B. subtilis, Japan
BKE03750 (yclJ::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTATATCCTCCGGTTGTT,  downstream forward: _UP4_ACTGTGTGGGGAGTAGGGTA
BKK03750 (yclJ::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTATATCCTCCGGTTGTT,  downstream forward: _UP4_ACTGTGTGGGGAGTAGGGTA
References
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706983E6942E883D3A9D45693E7B4015AEABE60B

Page visits: 4436

Time of last update: 2025-04-10 05:09:37

Author of last update: Melvin.boenninger