gntR

gntR
168

transcriptional repressor (GntR family) of the gntR-gntK-gntP-gntZ operon

Locus
BSU_40050
Molecular weight
28.13 kDa
Isoelectric point
5.26
Protein length
243 aaSequenceBlast
Gene length
732 bpSequenceBlast
Function
regulation of gluconate utilization
Product
transcriptional repressor of the gluconate operon
Essential
no
Synonyms
gntR
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1802 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
4,113,417  4,114,148
The protein
Protein family
GntR family of transcription factors
Domains
HTH gntR-type domain (aa 17-83) (according to UniProt)
Structure
7U5Q (PDB) (GntR family regulator from Brucella melitensis, corresponding to aa 13 ... 167, 26.9% identity)
P10585 (AlphaFold)
Effectors of protein activity
gluconate acts as molecular inducer
Expression and Regulation
Operons
Genes
gntR-gntK-gntP-gntZ
Description
PubMed
Regulation
induced by gluconate (GntR) PubMed
Regulatory mechanism
GntR: repression, PubMed, in gntR regulon
CcpA: repression, PubMed, in ccpA regulon
AbrB: activation, PubMed, in abrB regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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gntR→gntZ

2025-04-08 12:06:59

ghost

86

a4a9f34acee86d883fafe2368089737d1c13df10

02F8B40AEEBB8D4A2614150F30482A3F72134EF4

Biological materials
Mutant
BKE40050 (gntR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATACACTCACCTTCCTCAC,  downstream forward: _UP4_CTGGCAAAAGGAGCTGAATA
BKK40050 (gntR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATACACTCACCTTCCTCAC,  downstream forward: _UP4_CTGGCAAAAGGAGCTGAATA
References
Reviews
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Original Publications
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1C566E54F8EF1A17A365FC49DFDA452AC5D0CA64

Page visits: 4671

Time of last update: 2025-04-13 20:07:17

Author of last update: Jstuelk