resA

resA
168

extracytoplasmic thioredoxin, cytochrome c biogenesis, reduces disulfide bonds in apo-cytochrome prior to the attachment of heme

Locus
BSU_23150
Molecular weight
20.76 kDa
Isoelectric point
8.37
Protein length
179 aaSequenceBlast
Gene length
540 bpSequenceBlast
Function
cytochrome c biogenesis
Product
extracytoplasmic thioredoxin
Essential
no
Synonyms
resA, ypxA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1225 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,420,804 → 2,421,343
Phenotypes of a mutant
essential according to Kobayashi et al., but inactivation of resA was reported by Erlendsson et al. and by Meeske et al.
inactivation of ''resA'' reduces sporulation efficiency to 45.6% that of wild type cells; delayed entry into sporulation PubMed
The protein
Protein family
Thioredoxin family (according to UniProt)
Domains
Thioredoxin domain (aa 36-174) (according to UniProt)
Structure
3C73 (PDB)
P35160 (AlphaFold)
Paralogous protein(s)
StoA, YneN
Localization
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
rluB-resA-resB-resC-resD-resE
Description
PubMed
Open in new tab

rluB→recA

2025-04-03 13:26:21

Jstuelk

108

810e88212899b5da40206112287802e7d6377a71

48F6784365F7D14D1F54674DD0C766FFA75949EC

Genes
resA-resB-resC-resD-resE
Description
PubMed
Regulation
expressed under anaerobic conditions (ResD) PubMed
Regulatory mechanism
ResD: activation, PubMed, in resD regulon
PhoP: activation, PubMed, in phoP regulon
CcpA: repression, PubMed, in ccpA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

resA→resE

2025-04-04 01:44:56

ghost

99

35cf88192088e7d30495dfc1ae6639ee89ad31fe

7099FE353EE3AD6D60FB99016C9CE5D3AB2282C2

Biological materials
Mutant
BKE23150 (ΔresA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTGTCCACTGCCCCCTTC,  downstream forward: _UP4_ATAAAACCCGGAGAGACTTC
BKK23150 (ΔresA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTGTCCACTGCCCCCTTC,  downstream forward: _UP4_ATAAAACCCGGAGAGACTTC
References
Reviews
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Original Publications
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F7D869F77E2275110737EF658C58FA1BF742D73F

Page visits: 3695

Time of last update: 2025-04-10 15:32:00

Author of last update: Jstuelk