nhaC

nhaC
168

Na /H antiporter

Locus
BSU_09680
Molecular weight
47.89 kDa
Isoelectric point
7.87
Protein length
453 aaSequenceBlast
Gene length
1362 bpSequenceBlast
Function
pH homeostasis
Product
Na /H  antiporter
Essential
no
Synonyms
nhaC, yheL
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1757 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,042,885  1,044,246
The protein
Protein family
NhaC Na(+)/H(+) (TC 2.A.35) antiporter family (with MleN, according to UniProt)
Structure
O07553 (AlphaFold)
Paralogous protein(s)
MleN
Localization
cell membrane (according to UniProt)
Expression and Regulation
Operons
Genes
nhaC
Description
PubMed
Regulation
subject to indirect positive regulation by CodY PubMed
Regulatory mechanism
NhaX: activation, (probably) PubMed, in nhaX regulon
Additional information
the mRNA is substantially stabilized upon depletion of RNase Y PubMed
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nhaC

2025-03-28 10:33:38

ghost

72

05df6feb822c992217af593bb94b33839dbaa66d

6E5BBB092E0808B01EE9EF7AA18F77B811E19034

Biological materials
Mutant
MGNA-A707 (yheL::erm), available at the NBRP B. subtilis, Japan
BKE09680 (nhaC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAAATAACACCCCATATTT,  downstream forward: _UP4_TAAAAAGAGCCCCGCTGTAA
BKK09680 (nhaC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAAATAACACCCCATATTT,  downstream forward: _UP4_TAAAAAGAGCCCCGCTGTAA
References
Reviews
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Original Publications
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A7F1B4C0D32E18773170BFBEEB94E5EF55C7DB97

Page visits: 5589

Time of last update: 2025-04-06 21:49:37

Author of last update: Melvin.boenninger