gerKA

gerKA
168

nutrient receptor

Locus
BSU_03700
Molecular weight
60.22 kDa
Isoelectric point
5.21
Protein length
544 aaSequenceBlast
Gene length
1635 bpSequenceBlast
Function
germination response to the combination of glucose, fructose, aspartate, and KCl
Product
part of the putative nutrient-gated GerKA-GerKB-GerKC ion channel
Essential
no
Synonyms
gerKA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5901 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
420,110 → 421,744
The protein
Catalyzed reaction/ biological activity
the GerKA-GerKB-GerKC ion channel likely releases ions from the spore core in response to asparagine, glucose, fructose and K+ to trigger Germination, this requires the gerB locus PubMed
Protein family
GerABKA family (according to UniProt)
Domains
contains multiple membrane-spanning domains PubMed
Structure
6O59 (PDB) (from B. megaterium, corresponds to aa 40 ... 299, 53.6% identity) PubMed
P49939 (AlphaFold)
Paralogous protein(s)
GerAA, YndD, GerBA, YfkQ
Localization
outer surface of the inner spore membrane PubMed
Additional information
700 molecules are present per spore PubMed
Expression and Regulation
Operons
Genes
gerKA-gerKC-gerKB
Description
PubMed
Regulation
expressed during sporulation (SigG, SpoVT) PubMed
Regulatory mechanism
SpoVT: repression, PubMed, in spoVT regulon
Sigma factors
SigG: sigma factor, PubMed, in sigG regulon
Additional information
700 molecules are present per spore PubMed
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gerKA→gerKB

2025-04-04 08:06:08

Jstuelk

117

2621476d83b6d6d9772912d035f86d1791de6cd2

5744A84AC240BED93491E29AB72B18EEE120A73F

Biological materials
Mutant
BKE03700 (ΔgerKA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATACACAAATACCTTTCCT,  downstream forward: _UP4_AAAGATTTGGAAGAAGGGGA
BKK03700 (ΔgerKA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATACACAAATACCTTTCCT,  downstream forward: _UP4_AAAGATTTGGAAGAAGGGGA
References
Reviews
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Original Publications
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EDB2F4C132211F01654F2A2ED3D220EC15CE6F22

Page visits: 5812

Time of last update: 2025-04-06 05:49:21

Author of last update: Jstuelk