tdh

tdh
168

L-threonine dehydrogenase

Locus
BSU_16990
Molecular weight
36.84 kDa
Isoelectric point
6.06
Protein length
347 aaSequenceBlast
Gene length
1044 bpSequenceBlast
Function
threonine utilization
Product
L-threonine dehydrogenase
Essential
no
E.C.
1.1.1.103
Synonyms
tdh
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1063 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,770,461  1,771,504
The protein
Catalyzed reaction/ biological activity
L-threonine + NAD+ --> (2S)-2-amino-3-oxobutanoate + H+ + NADH (according to UniProt)
Protein family
zinc-containing alcohol dehydrogenase family (according to UniProt)
Cofactors
NAD+ (according to UniProt)
Structure
2DQ4 (PDB) (from Thermus thermophilus, 47% identity, 63% similarity)
O31776 (AlphaFold)
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
tdh-kbl
Description
PubMed
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tdh→kbl

2025-04-04 08:06:06

Jstuelk

116

fab32661cd3503f53c153d1ea771a2cee697e21c

5A29EEF0FA10A4FBE2CF780104BE349FE0DA8B77

Biological materials
Mutant
BKE16990 (tdh::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTACAATCCTCCTTGAA,  downstream forward: _UP4_TTAATTCCATAAAGGGGGAT
BKK16990 (tdh::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTACAATCCTCCTTGAA,  downstream forward: _UP4_TTAATTCCATAAAGGGGGAT
References
Research papers
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Page visits: 2541

Time of last update: 2025-04-09 08:09:41

Author of last update: Jstuelk