kapD

kapD
168

3'-exoribonuclease, inhibitor of the KinA pathway to sporulation

Locus
BSU_31470
Molecular weight
23.68 kDa
Isoelectric point
6.38
Protein length
205 aaSequenceBlast
Gene length
618 bpSequenceBlast
Function
regulation of sporulation initiation
Product
3'-exoribonuclease, inhibitor of the KinA pathway to sporulation
Essential
no
E.C.
null
Synonyms
kapD, yugB
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5018 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,231,812  3,232,429
The protein
Catalyzed reaction/ biological activity
RNA degradation, e.g. the sigK mRNA PubMed
Protein family
DEDDh family of 3′-exoribonucleases PubMed
Domains
Exonuclease domain (aa 6-173) (according to UniProt)
Structure
O05231 (AlphaFold)
Localization
assembles onto the surface of the developing spore PubMed
cytoplasm (Homogeneous) PubMed
Expression and Regulation
Operons
Genes
kapD
Description
PubMed
Regulation
expressed during sporulation in the mother cell (SigE, SigK) PubMed
Sigma factors
SigK: sigma factor, PubMed, in sigK regulon
SigE: sigma factor, PubMed, in sigE regulon
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Array

2025-03-19 03:37:33

Jstuelk

13

9FD9A395387F09B571B4D05E85F61D453B2A71BF

9FD9A395387F09B571B4D05E85F61D453B2A71BF

Biological materials
Mutant
MGNA-A611 (kapD::erm), available at the NBRP B. subtilis, Japan
BKE31470 (kapD::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACCTTTTACACCTGCCTTT,  downstream forward: _UP4_TAAAAAACCCAATCTTTTGT
BKK31470 (kapD::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACCTTTTACACCTGCCTTT,  downstream forward: _UP4_TAAAAAACCCAATCTTTTGT
References
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Time of last update: 2025-04-10 08:23:31

Author of last update: Jstuelk