wapI

wapI
168

immunity protein, protects the cell against the toxic activity of WapA

Locus
BSU_39220
Molecular weight
16.29 kDa
Isoelectric point
4.42
Protein length
142 aaSequenceBlast
Gene length
429 bpSequenceBlast
Function
intercellular competition
Product
immunity protein
Essential
yes
Synonyms
wapI, yxxG
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

List of homologs in different organisms

This gene is a member of the following regulons

SigA regulon, DegU regulon, YvrHb regulon, WalR regulon

Gene
Coordinates
4,023,054 → 4,023,482
Phenotypes of a mutant
essential PubMed
severe growth defect  PubMed
The protein
Catalyzed reaction/ biological activity
WapI inhibits the toxic activity of WapA PubMed
Structure
Q07836 (AlphaFold)
Modification
phosphorylation on (Tyr-102 OR Ser-105) PubMed
Expression and Regulation
Operons
Genes
wapA-wapI
Description
PubMed
Regulation
repressed at high salt concentration (DegU-P) PubMed
Expression
expression is heterogeneous PubMed
Regulatory mechanism
DegU: repression, DegU-P, PubMed, in degU regulon
YvrHb: activation, PubMed, in yvrHb regulon
WalR: repression, PubMed, in walR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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wapA→wapI

2025-03-30 09:07:15

Jstuelk

157

ACCB16F95EA75BBC03E1DD4186EAB71F0DEDFADE

84D822AFD36349840C746076174D4353AE6A1D3C

Biological materials
Mutant
MGNA-B789 (yxxG::erm), available at the NBRP B. subtilis, Japan
BKE39220 (ΔwapI::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATTTCCTCCTCATTTAA,  downstream forward: _UP4_TAATTATAAATAATTTCTGC
BKK39220 (ΔwapI::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATTTCCTCCTCATTTAA,  downstream forward: _UP4_TAATTATAAATAATTTCTGC
References
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C7400733DB8835A204A7FF26C87A92A15C5F318C

Page visits: 5994

Time of last update: 2025-04-03 04:43:00

Author of last update: Bzhu