ahpA

ahpA
168

alkyl hydroperoxide reductase

Locus
BSU_14220
Molecular weight
20.30 kDa
Isoelectric point
4.49
Protein length
180 aaSequenceBlast
Gene length
543 bpSequenceBlast
Function
protection against peroxide stress
Product
alkyl hydroperoxide reductase
Essential
no
Synonyms
ahpA, ykuU
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0450 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,492,261 → 1,492,803
The protein
Catalyzed reaction/ biological activity
[protein]-dithiol + hydroperoxide --> [protein]-disulfide + alcohol + H2O (according to UniProt)
Protein family
peroxiredoxin family (according to UniProt)
Domains
Thioredoxin domain (aa 4-165) (according to UniProt)
Structure
4XCS (PDB) (human peroxiredoxin, 48% identity)
O34564 (AlphaFold)
Paralogous protein(s)
AhpC
Expression and Regulation
Operons
Genes
ahpA-ahpT
Description
PubMed
Regulatory mechanism
AbrB: repression, PubMed, in abrB regulon
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ahpA→ahpT

2025-04-06 04:00:02

ghost

98

db3a077f5db973f301f5c2b07584b017a7d043c3

86001A08BE15B429348F69EB0340A4C6602B0430

Biological materials
Mutant
GP1729 ahpAT::kan trpC2 available at Jörg Stülkes lab
MGNA-B343 (ykuU::erm), available at the NBRP B. subtilis, Japan
BKE14220 (ΔahpA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATGTATCCCTCCAATTT,  downstream forward: _UP4_TAATTCTTTCCAAGAACGAA
BKK14220 (ΔahpA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATGTATCCCTCCAATTT,  downstream forward: _UP4_TAATTCTTTCCAAGAACGAA
References
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Time of last update: 2025-04-11 00:01:46

Author of last update: Melvin.boenninger