upp

upp
168

uracil phosphoribosyltransferase

Locus
BSU_36890
Molecular weight
22.89 kDa
Isoelectric point
5.86
Protein length
209 aaSequenceBlast
Gene length
630 bpSequenceBlast
Function
UMP synthesis
Product
uracil phosphoribosyltransferase
Essential
no
E.C.
2.4.2.9
Synonyms
upp, ipc-35d
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0035 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,788,426  3,789,055
The protein
Catalyzed reaction/ biological activity
diphosphate + UMP --> 5-phospho-α-D-ribose 1-diphosphate + uracil (according to UniProt)
Protein family
UPRTase family (single member, according to UniProt)
Structure
2EHJ (PDB) (from Escherichia coli, 52% identity, 73% similarity)
P39149 (AlphaFold)
Expression and Regulation
Operons
Genes
upp
Description
PubMed
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upp

2025-04-06 07:31:11

ghost

70

5b6d07109482e761a99c37bac81017b7fb70f119

7AFED01A3A8B31274B2D1219E39AEBCE42630E25

Biological materials
Mutant
1A832 (no resistance), PubMed, available at BGSC
BKE36890 (upp::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATACTGTGTTTCAGCTCCT,  downstream forward: _UP4_TAAAAAATGAAATCCCCAAA
BKK36890 (upp::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATACTGTGTTTCAGCTCCT,  downstream forward: _UP4_TAAAAAATGAAATCCCCAAA
References
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Page visits: 2729

Time of last update: 2025-04-06 07:46:57

Author of last update: Jstuelk