plsX

plsX
168

acyl-acyl carrier protein (ACP):phosphate acyltransferase, catalyzes the synthesis of the intermediate fatty acyl-phosphate (acyl-PO4)

Locus
BSU_15890
Molecular weight
35.61 kDa
Isoelectric point
5.49
Protein length
333 aaSequenceBlast
Gene length
1002 bpSequenceBlast
Function
biosynthesis of phospholipids
Product
acyl-acyl carrier protein (ACP):phosphate acyltransferase
Essential
yes
E.C.
2.3.1.n2
Synonyms
plsX, ylpD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0416 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,662,547  1,663,548
Phenotypes of a mutant
essential PubMed
depletion results in sporulation deficiency (via SpoIIR) PubMed
a ts mutant forms an abberant Z-ring and has a cell division defect PubMed
depletion results in accumulation of malonyl-CoA and of long-chain-ACPs PubMed
The protein
Catalyzed reaction/ biological activity
catalyzes the synthesis of the intermediate fatty acyl-phosphate (acyl-PO4)
fatty acyl-[ACP] + phosphate --> acyl phosphate + holo-[ACP] (according to UniProt)
Protein family
plsX family (single member, according to UniProt)
Structure
1VI1 (PDB) PubMed
6A1K (PDB) PubMed
P71018 (AlphaFold)
Localization
localizes to regions of increased fluidity in the membrane (via a short amphipathic α-peptide) PubMed
uniformly distributed on the membrane of most cells, but occasionally appears as membrane foci as well PubMed
in the presence of daptomycin, PlsX delocalizes from the membrane to the cytoplasm PubMed
Expression and Regulation
Operons
Genes
fapR-plsX-fabD-fabG-acpA
Description
PubMed
Regulation
''FapR'': repressed in the absence of malonyl-CoA or malonyl-ACP (FapR) PubMed
expression is reduced in motile cells as compared to non-motile cells PubMed
Regulatory mechanism
FapR: repression, PubMed, in fapR regulon
ComA: activation, (ComA) PubMed, in comA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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fapR→acpA

2025-04-07 00:16:46

Jstuelk

173

FFBE1C006C18216F03207DE6CCE7201A900066A3

A19B82B645D7251903097316A08D79733FD80DE9

Biological materials
Two-hybrid system
B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Matsumoto lab PubMed
References
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Time of last update: 2025-04-16 00:06:16

Author of last update: Jstuelk