hutU

hutU
168

urocanase

Locus
BSU_39360
Molecular weight
60.43 kDa
Isoelectric point
5.66
Protein length
552 aaSequenceBlast
Gene length
1659 bpSequenceBlast
Function
histidine utilization
Product
urocanase
Essential
no
E.C.
4.2.1.49
Synonyms
hutU
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2987 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
4,043,574 → 4,045,232
The protein
Catalyzed reaction/ biological activity
4-imidazolone-5-propanoate --> H2O + trans-urocanate (according to UniProt)
Protein family
urocanase family (single member, according to UniProt)
Structure
2FKN (PDB)
P25503 (AlphaFold)
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
hutP-hutH-hutU-hutI-hutG-hutM
Description
PubMed
Regulation
induced by histidine (HutP) PubMed
Regulatory mechanism
CcpA: repression, PubMed, in ccpA regulon
CodY: repression, PubMed, in codY regulon
HutP: antitermination, at a protein-dependent RNA switch located between hutP and hutH PubMed, in hutP regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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hutP→hutM

2025-04-03 13:30:05

ghost

154

cf3eb91928f3fe61cbc0cd204535c4f9c144314a

0AE45FCE38B0E774CFFC5F6A0A98EEDF6B02F4D4

Biological materials
Mutant
BKE39360 (ΔhutU::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AGTCATATGTTCATCCCCCT,  downstream forward: _UP4_ATGCAAAAATAAAGGAGTGA
BKK39360 (ΔhutU::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AGTCATATGTTCATCCCCCT,  downstream forward: _UP4_ATGCAAAAATAAAGGAGTGA
References
Reviews
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Original Publications
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ED6002BB56B96F9A2B4F80CA050518B266000E55

Page visits: 2722

Time of last update: 2025-04-10 05:33:55

Author of last update: Melvin.boenninger