hemL

hemL
168

glutamate-1-semialdehyde aminotransferase

Locus
BSU_28120
Molecular weight
46.29 kDa
Isoelectric point
5.05
Protein length
430 aaSequenceBlast
Gene length
1290 bpSequenceBlast
Function
heme biosynthesis
Product
glutamate-1-semialdehyde aminotransferase
Essential
no
E.C.
5.4.3.8
Synonyms
hemL, hemK
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0001 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,872,880 → 2,874,172
The protein
Catalyzed reaction/ biological activity
(S)-4-amino-5-oxopentanoate --> 5-aminolevulinate (according to UniProt)
Protein family
Class-III pyridoxal-phosphate-dependent aminotransferase family (according to UniProt)
Cofactors
PLP (according to UniProt)
Structure
3BS8 (PDB) PubMed
P30949 (AlphaFold)
Paralogous protein(s)
GsaB
Expression and Regulation
Operons
Genes
hemA-hemX-hemC-hemD-hemB-hemL
Description
PubMed
Regulation
induced by hydrogen peroxide (PerR) PubMed
Regulatory mechanism
PerR: repression, PubMed, in perR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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hemA→hemL

2025-03-29 16:29:02

ghost

108

64840dd729762069005c4bd541ed0ddec6e74ace

168BC8B91CBFE3EA050DA8A9187C8C67D6BBE4F9

Biological materials
Mutant
BKE28120 (ΔhemL::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTGCCTCAACTCCTGTC,  downstream forward: _UP4_TAAGAGTGAAAACCGGTATC
BKK28120 (ΔhemL::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTGCCTCAACTCCTGTC,  downstream forward: _UP4_TAAGAGTGAAAACCGGTATC
References
Reviews
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Original Publications
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A54B2C86638D474F5F892003B42C535B5B39A42E

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Time of last update: 2025-04-13 19:00:22

Author of last update: Melvin.boenninger