gtaB

gtaB
168

major vegetative UTP-glucose-1-phosphate uridylyltransferase, general stress protein

Locus
BSU_35670
Molecular weight
32.92 kDa
Isoelectric point
4.91
Protein length
292 aaSequenceBlast
Gene length
879 bpSequenceBlast
Function
biosynthesis of teichoic acid
Product
UTP-glucose-1-phosphate uridylyltransferase
Essential
no
E.C.
2.7.7.9
Synonyms
gtaB
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1210 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,665,629 → 3,666,507
Phenotypes of a mutant
cells are bent and distended due to the lack of glucolipids PubMed
the inactivation of ''gtaB suppresses the poor and filametous growth of the whiA zapA'' double mutant PubMed
inactivation of ''gtaB'' reduces sporulation efficiency to 0.1% that of wild type cells; smaller, wider mother cells with small forespores PubMed
resistant to phage SPO1 PubMed
defective in Swarming motility (periodic cessation and reinitiation of Swarming motility, terracing colonies) PubMed
The protein
Catalyzed reaction/ biological activity
produces UDP-glucose from UTP and glucose-1-phosphate PubMed
Protein family
UDPGP type 2 family (with YngB and YtdA, according to UniProt)
Structure
7B1R (PDB) (YngB, 58% identity) PubMed
2E3D (PDB) (from E. coli, 44% identity, 61% similarity) PubMed
Q05852 (AlphaFold)
Modification
phosphorylated on Arg-76 PubMed
phosphorylated on ser/ thr/ tyr PubMed
Paralogous protein(s)
YtdA, YngB
Expression and Regulation
Operons
Genes
gtaB
Description
PubMed
Regulation
induced by stress (SigB) PubMed
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigB: sigma factor, PubMed, in sigB regulon
Open in new tab

gtaB

2025-04-05 23:35:43

ghost

79

e2318a80c3fe1879f4ffcefc26f57849c6b3de32

18F2CD44FC5C224E4FD287E184EC1CA768C4BB8B

Biological materials
Mutant
BKE35670 (ΔgtaB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTAAAAGGCACCTTCCT,  downstream forward: _UP4_TAAACAAAAAGGCTATTGGA
BKK35670 (ΔgtaB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTAAAAGGCACCTTCCT,  downstream forward: _UP4_TAAACAAAAAGGCTATTGGA
References
Loading

D368988F85D8436DD424B0B4A1591BDF092A8EA7

Page visits: 9035

Time of last update: 2025-04-06 05:20:55

Author of last update: Jstuelk