gpsA

gpsA
168

glycerol-3-phosphate dehydrogenase (NAD)

Locus
BSU_22830
Molecular weight
37.28 kDa
Isoelectric point
6.23
Protein length
345 aaSequenceBlast
Gene length
1038 bpSequenceBlast
Function
biosynthesis of phospholipids
Product
glycerol-3-phosphate dehydrogenase (NAD)
Essential
no
E.C.
1.1.1.94
Synonyms
gpsA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0240 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,389,151  2,390,188
Phenotypes of a mutant
essential PubMed, non-essential according to PubMed
poor growth PubMed
poorly transformable PubMed
defective in biofilm formation PubMed
The protein
Catalyzed reaction/ biological activity
NAD+ + sn-glycerol 3-phosphate --> dihydroxyacetone phosphate + H+ + NADH (according to UniProt)
NADP+ + sn-glycerol 3-phosphate --> dihydroxyacetone phosphate + H+ + NADPH (according to UniProt)
Protein family
NAD-dependent glycerol-3-phosphate dehydrogenase family (single member, according to UniProt)
Structure
3K96 (PDB) (from Coxiella burnetii RSA 493, 37% identity, 59% similarity)
P46919 (AlphaFold)
Localization
cytoplasm PubMed
Expression and Regulation
Operons
Genes
engA-gpsA
Description
PubMed
Open in new tab

engA→gpsA

2025-03-27 22:37:21

Jstuelk

117

e742857757b54cfd3dbd31d4c2a8732ae1d6f10f

447F965D334A595E929D73835DC559433A0B536E

Genes
yphA-seaA-ypzH-engA-gpsA
Description
PubMed
Open in new tab

yphA→gpsA

2025-03-10 05:48:31

Jstuelk

127

59d7f332f8e66c2f3ab828b44d7b5670bff82244

CC6F80D7EB8E18FBBD197DB0376D1D6AFBFC5A02

Additional information
highly expressed at high iron concentrations PubMed
Biological materials
Mutant
BKE22830 (gpsA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTTCATGTTTGATTCACACC,  downstream forward: _UP4_TAAAAGTGTCAATCAAATGG
BKK22830 (gpsA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTTCATGTTTGATTCACACC,  downstream forward: _UP4_TAAAAGTGTCAATCAAATGG
References
Loading

8440C1DBE485BB9EF2904FAA5D709A574C3819A4

Page visits: 5108

Time of last update: 2025-04-10 00:18:44

Author of last update: Jstuelk