dapA

dapA
168

dihydrodipicolinate synthase

Locus
BSU_16770
Molecular weight
30.89 kDa
Isoelectric point
4.93
Protein length
290 aaSequenceBlast
Gene length
873 bpSequenceBlast
Function
biosynthesis of lysine and peptidoglycan
Product
dihydrodipicolinate synthase
Essential
yes
E.C.
4.2.1.52
Synonyms
dapA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

List of homologs in different organisms, belongs to COG0329 (Galperin et al., 2021)

This gene is a member of the following regulons

SigK regulon, SigA regulon

Gene
Coordinates
1,748,368  1,749,240
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
L-aspartate 4-semialdehyde + pyruvate --> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (according to UniProt)
Protein family
DapA family (with YcbC, according to UniProt)
Structure
3CPR (PDB) (from Corynebacterium glutamicum, 39% identity, 58% similarity) PubMed
Q04796 (AlphaFold)
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
asd-dapG-dapA
Description
PubMed
Sigma factors
SigK: sigma factor, PubMed, in sigK regulon
SigA: sigma factor, PubMed, in sigA regulon
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asd→dapA

2025-03-16 18:45:11

ghost

101

26b99709bb2d46d49ca998bee33208e722bad3f7

5716FEABC6E16C3675FEA484CEBA95D8F93F13D1

Genes
spoVFA-spoVFB-asd-dapG-dapA
Description
PubMed
Regulation
expressed late during sporulation in the mother cell (SigK) PubMed
Sigma factors
SigK: sigma factor, PubMed, in sigK regulon
Open in new tab

spoVFA→dapA

2025-03-21 22:03:33

ghost

250

9f1758bf801d23548827e9d03f6ca9d0c2e6746d

C373CB045AB9232B86B60761B90C3510E98A06A8

References
Reviews
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Original Publications
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00B4CA4E25858A56F9D4E0ADEE2643F203FEC613

Page visits: 4225

Time of last update: 2025-04-06 10:20:24

Author of last update: Melvin.boenninger