atpD

atpD
168

ATP synthase, part of the F1 complex (subunit beta)

Locus
BSU_36810
Molecular weight
51.26 kDa
Isoelectric point
4.61
Protein length
473 aaSequenceBlast
Gene length
1422 bpSequenceBlast
Function
ATP synthesis
Product
ATP synthase (subunit beta))
Essential
no
E.C.
3.6.3.14
Synonyms
atpD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0055 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,781,491 3,782,912
The protein
Catalyzed reaction/ biological activity
ATP + 4 H+ + H2O --> ADP + 5 H+ + phosphate (according to UniProt), ATP synthesis see a video
Protein family
ATPase alpha/beta chains family (with AtpA and FliI, according to UniProt)
Structure
1SKY (PDB) (AtpA-AtpD complex from Bacillus sp., 88% identity) PubMed
see here an overview on ATPase structure (PDB)
P37809 (AlphaFold)
Modification
phosphorylated on ser/ thr/ tyr PubMed
Effectors of protein activity
ATPase activity is inhibited upon binding of Mg-ADP to AtpD PubMed
Localization
membrane PubMed
peripheral via theF0 complex
Additional information
belongs to the 100 most abundant proteins PubMed
Expression and Regulation
Operons
Genes
atpI-atpB-atpE-atpF-atpH-atpA-atpG-atpD-atpC
Description
PubMed
Regulation
Rel dependent downregulation (Class I) during stringent response PubMed
the mRNA is processed between atpI and atpB by RNase Y, this requires the RicA-RicF-RicT complex PubMed
Regulatory mechanism
stringent response: negative regulation, in stringent response
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atpI→atpC

2025-04-09 21:43:28

Jstuelk

138

c30b9914547f38015d481b305686327f4f8f18d8

1C7DF7F5F812B06EFE55424A9900C106B30D346A

Biological materials
Mutant
GP4500 (trpC2 ΔatpD::neo), available in Jörg Stülke's lab
BKE36810 (atpD::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATCGCTATCCCTCCTGACA, downstream forward: _UP4_TAATCTGGTCCTAGGAGGGT
BKK36810 (atpD::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATCGCTATCCCTCCTGACA, downstream forward: _UP4_TAATCTGGTCCTAGGAGGGT
References
Reviews
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Original Publications
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2A566C2CF8F7B86E05EEF4B7A268E8C102070025

Page visits: 4777

Time of last update: 2025-04-10 18:40:22

Author of last update: Robert.warneke