aroA
168
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase / chorismate mutase-isozyme 3
Locus
BSU_29750
Molecular weight
39.38 kDa
Isoelectric point
5.34
Function
biosynthesis of aromatic amino acids
Product
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase /
Essential
no
E.C.
2.5.1.54
Synonyms
aroA, aroG
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2876 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,045,445 3,046,521
The protein
Catalyzed reaction/ biological activity
D-erythrose 4-phosphate + H2O + phosphoenolpyruvate --> 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate (according to UniProt)
chorismate --> prephenate (according to UniProt)
Protein family
class-I DAHP synthase family (single member, according to UniProt)
Chorismate mutase domain (aa 1-90) (according to UniProt)
Structure
1VR6 (PDB) (from Thermotoga maritima, 51% identity, 68% similarity)
5GO2 (PDB) (chorismate mutase-like domain, with citrate) PubMed
Modification
phosphorylation on Ser-2 PubMed
phosphorylation on Thr-4 PubMed
phosphorylated on Arg-45 and Arg-301 PubMed
Cys126 is S-bacillithiolated by NaOCl stress in B. subtilis and other Bacillus species PubMed
Effectors of protein activity
subject to feedback inhibition PubMed
Additional information
belongs to the 100 most abundant proteins PubMed
Expression and Regulation
Operons
Biological materials
Mutant
References
Loading
Page visits: 7119
Time of last update: 2025-04-05 16:16:28
Author of last update: Jstuelk