yfmR

yfmR
168

translation factor, housekeeping subfamily F ABC ATPase, prevents ribosome stalling at proline-rich motifs during early elongation in the absence of Efp

Locus
BSU_07370
Molecular weight
70.94 kDa
Isoelectric point
5
Protein length
629 aaSequenceBlast
Gene length
1890 bpSequenceBlast
Function
prevents ribosome stalling in the absence of Efp
Product
housekeeping subfamily F ABC ATPase
Essential
no
Synonyms
yfmR
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0488 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
809,557 → 811,446
Phenotypes of a mutant
an efp yfmR double mutant is not viable PubMed
The protein
Catalyzed reaction/ biological activity
resolves ribosome stalling on Asp-Pro motifs PubMed
Protein family
ABC transporter superfamily (according to UniProt)
ABCF ATPase subfamily PubMed
Domains
2 ABC transporter domains (aa 4-255, aa 319-537) (according to UniProt)
Structure
3J5S (PDB) (EttA from E. coli, 36% identity) PubMed
4FIN (PDB) (EttA from E. coli, 36% identity) PubMed
O06476 (AlphaFold)
Paralogous protein(s)
YdiF, YkpA, YfmM
Expression and Regulation
Operons
Genes
yfmR
Description
PubMed
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yfmR

2025-03-16 15:51:33

Jstuelk

109

1b38e4a6d2353cfe6e05118405b1adba97115adc

8ACEBEB1E26E449170693AC6BD09F5E731B11403

Biological materials
Mutant
MGNA-C234 (yfmR::erm), available at the NBRP B. subtilis, Japan
BKE07370 (ΔyfmR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGGTTCCTATCAATCCTC,  downstream forward: _UP4_TAAAAAGCGTGGCCGCAGCA
BKK07370 (ΔyfmR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGGTTCCTATCAATCCTC,  downstream forward: _UP4_TAAAAAGCGTGGCCGCAGCA
References
Reviews
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Original Publications
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F69F15198ACF8A8347C450EEC09F000EECEDEC41

Page visits: 2330

Time of last update: 2025-04-05 14:48:53

Author of last update: Jstuelk