tcyA

tcyA
168

cystine and diaminopimelate ABC transporter (binding protein)

Locus
BSU_03610
Molecular weight
29.32 kDa
Isoelectric point
9.12
Protein length
268 aaSequenceBlast
Gene length
807 bpSequenceBlast
Function
cystine uptake
Product
cystine and diaminopimelate ABC transporter (binding protein)
Essential
no
Synonyms
tcyA, yckK
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0834 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
410,656  411,462
The protein
Catalyzed reaction/ biological activity
uptake of cystine and diaminopimelate PubMed
Protein family
bacterial solute-binding protein 3 family (according to UniProt)
Structure
2YLN (PDB) (from Neisseria gonorrhoeae, 54% identity) PubMed
P42199 (AlphaFold)
Paralogous protein(s)
YckB
Localization
attached to the membrane via TcyB PubMed
Expression and Regulation
Operons
Genes
tcyA-tcyB-tcyC
Description
PubMed
Regulation
strongly repressed in response to glucose starvation in M9 medium PubMed
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tcyA→tcyC

2025-03-28 06:06:34

Jstuelk

123

4d611b63f86c92d9ecb8c2daaa53e692acd195f5

768128284DD011A0C571EBC11696DA21513C3B17

Biological materials
Mutant
GP4658 (trpC2 ΔtcyA::neo), available in Jörg Stülke's lab
GP4667 (trpC2 ΔtcyA::lox72), available in Jörg Stülke's lab
BKE03610 (tcyA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTTATTCCCCACTTTTC,  downstream forward: _UP4_GAAGATGTTTCTAAATAATC
BKK03610 (tcyA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTTATTCCCCACTTTTC,  downstream forward: _UP4_GAAGATGTTTCTAAATAATC
References
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Page visits: 4882

Time of last update: 2025-04-11 02:44:36

Author of last update: Jstuelk