ylmE
168

pyridoxal phosphate-binding protein, involved in controlling the availability of coenzyme A

Locus

BSU_15380

Molecular weight

25.56 kDa

Isoelectric point

5.55

Protein length

230 aaSequenceBlast

Gene length

693 bpSequenceBlast

Function

control of the CoA pool

Product

pyridoxal phosphate-binding protein

Essential

Synonyms

ylmE

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

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Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0325 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

1,610,170 1,610,862

The protein

Catalyzed reaction/ biological activity

while the protein was described as an amino acid racemase important for biofilm formation PubMed, no racemase activity was detected in in vitro assays with a functionally active protein PubMed

Protein family

pyridoxal phosphate-binding protein YggS/PROSC family (single member, according to UniProt)

Cofactors

pyridoxal phosphate PubMed

Structure

1W8G (PDB) (the structure of YggS from E. coli 33% identity, 61% similarity)

O31727 (AlphaFold)

Expression and Regulation

Operons

Genes

ylmD-ylmE-sepF-ylmG-ylmH

Description

PubMed

Regulation

repressed under conditions that trigger sporulation (Spo0A) PubMed

Regulatory mechanism

Spo0A: repression, PubMed, in spo0A regulon

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Biological materials

Mutant

MGNA-B363 (ylmE::erm), available at the NBRP B. subtilis, Japan

BKE15380 (ylmE::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_ATTATCAACAACACGCAAGA, downstream forward: _UP4_AATGAAACAGGGGGTGTACA

BKK15380 (ylmE::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_ATTATCAACAACACGCAAGA, downstream forward: _UP4_AATGAAACAGGGGGTGTACA

References

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Time of last update: 2025-04-10 09:14:30

Author of last update: Jstuelk

ylmE 168

ylmE
168