yhdN

yhdN
168

general stress protein, broad specificity aldo-keto reductase that converts MG to acetol

Locus
BSU_09530
Molecular weight
37.16 kDa
Isoelectric point
4.77
Protein length
331 aaSequenceBlast
Gene length
996 bpSequenceBlast
Function
detoxification of methylglyoxal
Product
aldo/keto reductase, specific for NADP
Essential
no
Synonyms
yhdN
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0667 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,030,265  1,031,260
Phenotypes of a mutant
increased sensitivity to methylglyoxal PubMed
The protein
Catalyzed reaction/ biological activity
methylglyoxal ---> acetol PubMed
Protein family
Aldo/keto reductase family (according to UniProt)
Cofactors
NADPH PubMed
Structure
1PZ1 (PDB) PubMed
P80874 (AlphaFold)
Paralogous protein(s)
YccK, YcsN, IolS
Expression and Regulation
Operons
Genes
yhdN-plsC
Description
PubMed
Regulation
induced by stress (SigB) PubMed
Regulatory mechanism
FapR: repression, PubMed, in fapR regulon
Sigma factors
SigB: sigma factor, PubMed, in sigB regulon
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yhdN→plsC

2025-04-04 02:07:17

ghost

82

69ae613ea81b2953398d70a3ed690d8db10f11e7

5361FA2AD8C5E573BDF85729CDBE95E925E36F37

Biological materials
Mutant
MGNA-A695 (yhdN::erm), available at the NBRP B. subtilis, Japan
BKE09530 (yhdN::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTGTGCCACTCCTTCACT,  downstream forward: _UP4_TAACAAAAGCTGAGGGCGAA
BKK09530 (yhdN::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTGTGCCACTCCTTCACT,  downstream forward: _UP4_TAACAAAAGCTGAGGGCGAA
References
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4DF9B105ABA64AFD5106EE75FCC9EFAB52BEFC83

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Time of last update: 2025-04-06 06:24:20

Author of last update: Jstuelk