UvrA

• Description: excinuclease ABC (subunit A)
  
  

Gene name	uvrA
Synonyms
Essential	no
Product	excinuclease ABC (subunit A)
Function	DNA repair after UV damage
Gene expression levels in SubtiExpress: uvrA
Interactions involving this protein in SubtInteract: UvrA
MW, pI	105 kDa, 5.843
Gene length, protein length	2871 bp, 957 aa
Immediate neighbours	yvzB, uvrB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA repair/ recombination

This gene is a member of the following regulons

LexA regulon

The gene

Basic information

• Locus tag: BSU35160

Database entries

• BsubCyc: BSU35160

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: UvrA subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • Mfd-UvrA PubMed
  • UvrA-UvrB PubMed

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• BsubCyc: BSU35160

• Structure: 2R6F (Geobacillus stearothermophilus)

• UniProt: O34863

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: uvrB-uvrA (according to DBTBS)

• Expression browser: uvrA PubMed

• Sigma factor:

• Regulation:
  • induced upon DNA damage (LexA) PubMed

• Regulatory mechanism:
  • LexA: transcription repression PubMed

• Additional information:
  • during sporulation expressed both in the forespore and the mother cell PubMed
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 212 PubMed

Biological materials

• mutant: GP1175 (del uvrAB::ermC) (available in the Stülke lab)

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: