sdpA
168

required for SdpC toxin maturation

Locus

BSU_33750

Molecular weight

18.51 kDa

Isoelectric point

9.77

Protein length

158 aaSequenceBlast

Gene length

477 bpSequenceBlast

Function

maturation of the SdpC toxin

Product

unknown

Essential

Synonyms

sdpA, yvaW

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

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Categories containing this gene/protein

List of homologs in different organisms

This gene is a member of the following regulons

Gene

Coordinates

3,464,289 3,464,765

The protein

Structure

O34889 (AlphaFold)

Paralogous protein(s)

YitP

Localization

cytoplasm PubMed

Expression and Regulation

Operons

Genes

sdpA-sdpB-sdpC

Description

PubMed

Regulation

expressed under conditions that trigger sporulation (Spo0A) PubMed

Expression

expression is heterogeneous PubMed

Regulatory mechanism

Spo0A: activation, PubMed, in spo0A regulon

Rok: repression, PubMed, in rok regulon

AbrB: repression, PubMed, in abrB regulon

Additional information

the amount of the mRNA is substantially decreased upon depletion of RNase Y PubMed

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Biological materials

Mutant

MGNA-A453 (yvaW::erm), available at the NBRP B. subtilis, Japan

BKE33750 (sdpA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTACAGTAATAATTCCCT, downstream forward: _UP4_GTATGAAGATATTAAATAGT

BKK33750 (sdpA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTACAGTAATAATTCCCT, downstream forward: _UP4_GTATGAAGATATTAAATAGT

References

Reviews

González-Pastor JE Cannibalism: a social behavior in sporulating Bacillus subtilis. FEMS microbiology reviews. 2011 May; 35(3):415-24. doi:10.1111/j.1574-6976.2010.00253.x. PMID:20955377

Original Publications

Yannarell SM, Beaudoin ES, Talley HS, Schoenborn AA, Orr G, Anderton CR, Chrisler WB, Shank EAExtensive cellular multi-tasking within Bacillus subtilis biofilms.mSystems. 2023 Aug 1; :e0089122. PMID: 37527273

Schoenborn AA, Yannarell SM, Wallace ED, Clapper H, Weinstein IC, Shank EADefining the expression, production, and signaling roles of specialized metabolites during Bacillus subtilis differentiation.Journal of bacteriology. 2021 Aug 30; :JB0033721. PMID: 34460312

Pérez Morales TG, Ho TD, Liu WT, Dorrestein PC, Ellermeier CD Production of the cannibalism toxin SDP is a multistep process that requires SdpA and SdpB. Journal of bacteriology. 2013 Jul; 195(14):3244-51. doi:10.1128/JB.00407-13. PMID:23687264

Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y. Molecular microbiology. 2011 Sep; 81(6):1459-73. doi:10.1111/j.1365-2958.2011.07777.x. PMID:21815947

Strauch MA, Bobay BG, Cavanagh J, Yao F, Wilson A, Le Breton Y Abh and AbrB control of Bacillus subtilis antimicrobial gene expression. Journal of bacteriology. 2007 Nov; 189(21):7720-32. . PMID:17720793

Albano M, Smits WK, Ho LT, Kraigher B, Mandic-Mulec I, Kuipers OP, Dubnau D The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions. Journal of bacteriology. 2005 Mar; 187(6):2010-9. . PMID:15743949

Fujita M, González-Pastor JE, Losick R High- and low-threshold genes in the Spo0A regulon of Bacillus subtilis. Journal of bacteriology. 2005 Feb; 187(4):1357-68. . PMID:15687200

Molle V, Fujita M, Jensen ST, Eichenberger P, González-Pastor JE, Liu JS, Losick R The Spo0A regulon of Bacillus subtilis. Molecular microbiology. 2003 Dec; 50(5):1683-701. . PMID:14651647

Blencke HM, Homuth G, Ludwig H, Mäder U, Hecker M, Stülke J Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways. Metabolic engineering. 2003 Apr; 5(2):133-49. . PMID:12850135

González-Pastor JE, Hobbs EC, Losick R Cannibalism by sporulating bacteria. Science (New York, N.Y.). 2003 Jul 25; 301(5632):510-3. . PMID:12817086

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Time of last update: 2025-04-10 17:26:52

Author of last update: Jstuelk

sdpA 168

sdpA
168