sbcD

sbcD
168

exonuclease SbcD homolog

Locus
BSU_10640
Molecular weight
43.25 kDa
Isoelectric point
5
Protein length
391 aaSequenceBlast
Gene length
1176 bpSequenceBlast
Function
unknown
Product
exonuclease SbcD homolog
Essential
no
Synonyms
sbcD, yixA
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0420 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,143,577  1,144,752
Phenotypes of a mutant
reduced resistance towards electron beams PubMed
reduced formation of rpsB or rpsE suppressor mutants after mitomycin treatment PubMed
The protein
Protein family
sbcD family (single member, according to UniProt)
Structure
4LTY (PDB) (from E. coli, corresponds to aa 1 - 314 of SbcD, 30% identity) PubMed
P23479 (AlphaFold)
Localization
Cytoplasm (Homogeneous) PubMed
Expression and Regulation
Operons
Genes
addB-addA-sbcD-sbcC-hlpB
Description
PubMed
Regulation
positive control by ComK PubMed
Regulatory mechanism
ComK: activation, in comK regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
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addB→hlpB

2025-04-03 20:37:41

ghost

169

045c7bb396e5f5521fcc2041130afbaac29b0bd8

E5051999C31DBE142375FC331C2F21A76C29910D

Biological materials
Mutant
GP894 (sbcD-sbcC::kan), available in Jörg Stülke's lab PubMed
BKE10640 (sbcD::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAATGCTTTCACCTCTCTT,  downstream forward: _UP4_GGCGTTGAAGAGGAGGATGC
BKK10640 (sbcD::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAAATGCTTTCACCTCTCTT,  downstream forward: _UP4_GGCGTTGAAGAGGAGGATGC
References
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Time of last update: 2025-04-03 11:53:24

Author of last update: Jstuelk