PbpX

• Description: penicillin-binding protein X
  
  

Gene name	pbpX
Synonyms
Essential	no
Product	penicillin-binding protein X
Function	endopeptidase
Gene expression levels in SubtiExpress: pbpX
MW, pI	43 kDa, 9.711
Gene length, protein length	1173 bp, 391 aa
Immediate neighbours	recA, rny
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, cell envelope stress proteins (controlled by SigM, V, W, X, Y)

This gene is a member of the following regulons

SigM regulon, SigX regulon

The gene

Basic information

• Locus tag: BSU16950

Phenotypes of a mutant

• increased sensitivity to lysozyme PubMed
• inactivation of pbpX strongly restores beta-lactam resistance in a sigM mutant PubMed

Database entries

• BsubCyc: BSU16950

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • extracellular (signal peptide) PubMed
  • localizes during sporulation to both asymmetric septa and the prespore Link to a summary

Database entries

• BsubCyc: BSU16950

• Structure:

• UniProt: O31773

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: pbpX PubMed

• Expression browser: pbpX PubMed

• Sigma factor: SigM PubMed, SigX PubMed

• Regulation:
  • expression is reduced in a SigV mutant PubMed

• Regulatory mechanism:

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 491 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed