malR

malR
168

two-component response regulator, regulation of malate uptake

Locus
BSU_31530
Molecular weight
26.82 kDa
Isoelectric point
5.98
Protein length
235 aaSequenceBlast
Gene length
708 bpSequenceBlast
Function
regulation of malate uptake
Product
two-component response regulator
Essential
no
Synonyms
malR, yufM
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG4565 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,238,751  3,239,458
Phenotypes of a mutant
unable to use malate as the single carbon source PubMed
The protein
Domains
Response regulatory domain (aa 3-119) (according to UniProt)
Structure
5LWK (PDB) (from Lactobacillus paracasei, N-terminal part, corresponds to aa 1 ... 122, 43% identity) PubMed
O05251 (AlphaFold)
Modification
phosphorylated by MalK on an Asp residue
Effectors of protein activity
phosphorylation likely affects DNA-binding activity
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
malR
Description
PubMed
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malR

2025-03-30 16:25:20

ghost

77

6c76e77b455436589517db1e42d034705f4be1b6

868ACD1F9DF75A4A0C38DCA819D69E996B7564DB

Genes
malK-malR
Description
PubMed
Open in new tab

malK→malR

2025-04-04 12:18:52

Jstuelk

70

4d0af3dc685749cd25b72d25b2068820a4e80caa

A1CE44BB5BE01A01460705F1FB2C87CE7994208A

Biological materials
Mutant
MGNA-A635 (yufM::erm), available at the NBRP B. subtilis, Japan
GP1301 (cat), available in Jörg Stülke's lab
BKE31530 (malR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTAATCATGATTTTCCTC,  downstream forward: _UP4_TAAGAAAACGCACTGCTTGC
BKK31530 (malR::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTAATCATGATTTTCCTC,  downstream forward: _UP4_TAAGAAAACGCACTGCTTGC
Labs working on this gene/protein
Stephane Aymerich, Microbiology and Molecular Genetics, INRA Paris-Grignon, France
References
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689CF50691E77E5A40437EF1E6B5083AF7CFCE08

Page visits: 5238

Time of last update: 2025-04-06 03:55:13

Author of last update: Melvin.boenninger