Difference between revisions of "IseA"
| (11 intermediate revisions by 3 users not shown) | |||
| Line 14: | Line 14: | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || protection against cell envelope stress | |style="background:#ABCDEF;" align="center"|'''Function''' || protection against cell envelope stress | ||
|- | |- | ||
| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU18380 iseA] |
| + | |- | ||
| + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=IseA IseA] | ||
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 19 kDa, 10.176 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 19 kDa, 10.176 | ||
| Line 22: | Line 24: | ||
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yoeA]]'', ''[[trnSL-Arg1]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yoeA]]'', ''[[trnSL-Arg1]]'' | ||
|- | |- | ||
| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU18380 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU18380 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU18380 DNA_with_flanks] |
|- | |- | ||
|- | |- | ||
| Line 29: | Line 31: | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
|- | |- | ||
| − | |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=iseA_2002637_2003182_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:iseA_expression.png|500px]] | + | |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=iseA_2002637_2003182_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:iseA_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU18380]] |
|- | |- | ||
|} | |} | ||
| Line 37: | Line 39: | ||
<br/><br/><br/><br/> | <br/><br/><br/><br/> | ||
<br/><br/><br/><br/> | <br/><br/><br/><br/> | ||
| − | |||
| − | |||
| − | |||
| − | |||
<br/><br/> | <br/><br/> | ||
| Line 59: | Line 57: | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU18380&redirect=T BSU18380] | ||
* '''DBTBS entry:''' no entry | * '''DBTBS entry:''' no entry | ||
| Line 97: | Line 96: | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU18380&redirect=T BSU18380] | ||
* '''Structure:''' | * '''Structure:''' | ||
| Line 119: | Line 119: | ||
** repressed by [[WalR]] {{PubMed|17581128}} | ** repressed by [[WalR]] {{PubMed|17581128}} | ||
** induced by vancomycin {{PubMed|17483219}} | ** induced by vancomycin {{PubMed|17483219}} | ||
| + | ** strongly induced in response to glucose starvation in M9 medium {{PubMed|23033921}} | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| Line 124: | Line 125: | ||
* '''Additional information:''' | * '''Additional information:''' | ||
| + | ** number of protein molecules per cell (minimal medium with glucose and ammonium): 188 {{PubMed|24696501}} | ||
=Biological materials = | =Biological materials = | ||
| Line 144: | Line 146: | ||
=References= | =References= | ||
| − | + | <pubmed>17581128,18761694,17483219, 20059685,22383849 23091053,23033921 23199363</pubmed> | |
| − | <pubmed>17581128,18761694,17483219, 20059685,22383849 </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Latest revision as of 09:59, 17 April 2014
- Description: inhibits in vitro activity of cell wall endopeptidases LytE and LytF, inhibits cell separation
| Gene name | iseA |
| Synonyms | yoeB |
| Essential | no |
| Product | inhibitor of autolysins |
| Function | protection against cell envelope stress |
| Gene expression levels in SubtiExpress: iseA | |
| Interactions involving this protein in SubtInteract: IseA | |
| MW, pI | 19 kDa, 10.176 |
| Gene length, protein length | 543 bp, 181 aa |
| Immediate neighbours | yoeA, trnSL-Arg1 |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
cell wall degradation/ turnover, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU18380
Phenotypes of a mutant
Database entries
- BsubCyc: BSU18380
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot), localized to cell separation sites
Database entries
- BsubCyc: BSU18380
- Structure:
- UniProt: O34841
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon: iseA PubMed
- Sigma factor:
- Regulation:
- Additional information:
- number of protein molecules per cell (minimal medium with glucose and ammonium): 188 PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
