sweC

sweC
168

cofactor of the FtsE-FtsX complex

Locus
BSU_24940
Molecular weight
16.88 kDa
Isoelectric point
9.01
Protein length
Gene length
Function
control of CwlO activity in peptidoglycan elongation
Product
cofactor of the FtsE-FtsX complex
Essential
no
E.C.
null
Synonyms
sweC, yqzC

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1559 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,576,717  2,577,181
Phenotypes of a mutant
synthetic lethal with LytE, this can be suppressed by point mutations in ftsE or ftsX PubMed
cells are shorter and fatter than wild-type, cells are bent and curved, both phenotypes depend on the presence of CwlO PubMed
defective in Swarming motility (prolonged period of immotility prior to Swarming) PubMed
The protein
Structure
cell membrane (integral), C-terminal cytoplasmic domain PubMed
Expression and Regulation
Operons
Genes
Description
Regulation
repressed under conditions that trigger sporulation (Spo0A) PubMed
Regulatory mechanism
Spo0A: repression, PubMed, in spo0A regulon
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sweDsweC

2025-01-05 23:47:05

Jstuelk

59

d3c26c5c0ad2b02d64f20f743f9b69d1f54de8a0

AC8611ADAB04045125A5F4EF9942EC21D42A527B

Biological materials
Mutant
MGNA-C484 (yqzC::erm), available at the NBRP B. subtilis, Japan
BKE24940 (sweC::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_AAATGCCTGAATGCCCCGTT,  downstream forward: _UP4_TAAAAAAACAGGCTGACTCA
BKK24940 (sweC::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_AAATGCCTGAATGCCCCGTT,  downstream forward: _UP4_TAAAAAAACAGGCTGACTCA
References
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Time of last update: 2025-01-30 00:58:34

Author of last update: Jstuelk