rsbU

rsbU
168

protein serine phosphatase, environmental PP2C, dephosphorylates RsbV

Locus
BSU_04700
Molecular weight
38.48 kDa
Isoelectric point
4.91
Protein length
335 aaSequenceBlast
Gene length
1008 bpSequenceBlast
Function
control of SigB activity
Product
protein serine phosphatase, environmental PP2C
Essential
no
E.C.
3.1.3.3
Synonyms
rsbU
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2208 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
521,019  522,026
The protein
Catalyzed reaction/ biological activity
O-phospho-L(or D)-serine + H2O --> L(or D)-serine + phosphate (according to UniProt)
Domains
PPM-type phosphatase domain (aa 123-333) (according to UniProt)
Cofactors
Mn2+ PubMed
Mg2+ PubMed
Structure
2J6Y (PDB) PubMed
P40399 (AlphaFold)
Expression and Regulation
Operons
Genes
rsbR-rsbS-rsbT-rsbU-rsbV-rsbW-sigB-rsbX
Description
PubMed
Regulation
''rsbV:'' induced by stress (SigB) PubMed
Regulatory mechanism
CcpA: repression, PubMed, in ccpA regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
SigB: sigma factor, PubMed, in sigB regulon
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rsbR→rsbX

2025-04-04 06:45:52

ghost

228

5f220975cc2493224a8aa0770ee2187c815a2127

3EFC8DC1AC54632D4F2AC30497749AB5CCA3A39F

Biological materials
Mutant
BKE04700 (rsbU::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CCTAAAATCCACGTTCTTAC,  downstream forward: _UP4_TAACGTCTGTCAGACGAGGG
BKK04700 (rsbU::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CCTAAAATCCACGTTCTTAC,  downstream forward: _UP4_TAACGTCTGTCAGACGAGGG
Labs working on this gene/protein
Bill Haldenwang, San Antonio, USA
Chet Price, Davis, USA homepage
Rick Lewis, Newcastle, UK homepage
References
Reviews
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Original Publications
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0B8381D2C724DAA724E4AFC67000F12AD112D13D

Page visits: 4900

Time of last update: 2025-04-07 04:57:32

Author of last update: Jstuelk