trpS

trpS
168

tryptophanyl-tRNA synthetase

Locus
BSU_11420
Molecular weight
37.04 kDa
Isoelectric point
6.54
Protein length
330 aaSequenceBlast
Gene length
993 bpSequenceBlast
Function
translation
Product
tryptophanyl-tRNA synthetase
Essential
yes
E.C.
6.1.1.2
Synonyms
trpS
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0180 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,218,113  1,219,105
Phenotypes of a mutant
essential PubMed
The protein
Catalyzed reaction/ biological activity
ATP + L-tryptophan + tRNATrp --> AMP + diphosphate + H+ + L-tryptophanyl-tRNATrp (according to UniProt)
Protein family
Class-I aminoacyl-tRNA synthetase family (according to UniProt)
Structure
3PRH (PDB) (Val144Pro mutant) PubMed
1BM2 (PDB) (complex with tryptophan, Geobacillus stearothermophilus)
1MAW (PDB) (complex with ATP, Geobacillus stearothermophilus)
P21656 (AlphaFold)
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
trpS
Description
PubMed
Regulation
induced by tryptophan limitation (T-box) PubMed
Additional information
A ncRNA is predicted between trpS and oppA PubMed
the T-box RNA is degraded by RNase Y PubMed
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trpS

2025-03-17 17:06:22

Bzhu

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Time of last update: 2025-04-05 15:17:15

Author of last update: Melvin.boenninger