tenI

tenI
168

thiazole tautomerase

Locus
BSU_11660
Molecular weight
22.78 kDa
Isoelectric point
8.13
Protein length
205 aaSequenceBlast
Gene length
618 bpSequenceBlast
Function
biosynthesis of thiamine
Product
thiazole tautomerase
Essential
no
E.C.
null
Synonyms
tenI
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0352 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,243,134 → 1,243,751
The protein
Catalyzed reaction/ biological activity
2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate --> 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate (according to UniProt)
Protein family
thiazole tautomerase family (single member, according to UniProt)
Structure
1YAD (PDB)
P25053 (AlphaFold)
Paralogous protein(s)
ThiE
Expression and Regulation
Operons
Genes
tenA-tenI-thiO-thiS-thiG-thiF-thiD
Description
PubMed
Regulation
repressed by thiamine (Thi-box) PubMed
antitermination is modulated by NusG-dependent transcription pausing just upstream of the Thi-box PubMed
the Thi-box RNA is degraded by RNase Y PubMed
Regulatory mechanism
Thi-box: RNA switch, via RNA switch, in Thi-box regulon
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tenA→thiD

2025-04-03 13:11:27

Jstuelk

127

A48634F4963321F6F5F59C5107F472325227A1B0

A1FEA45B91FD65F137EB4D1A0FCD88BC91331EAF

Biological materials
Mutant
BKE11660 (ΔtenI::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CGCTAGCTCTTCTACCGGCT,  downstream forward: _UP4_TCCCGCAAGCTAAAGGAGAT
BKK11660 (ΔtenI::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CGCTAGCTCTTCTACCGGCT,  downstream forward: _UP4_TCCCGCAAGCTAAAGGAGAT
References
Reviews
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Original Publications
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CA6AAE8AC5B5EF01A911B035F8782579CD876C08

Page visits: 2569

Time of last update: 2025-04-07 10:35:41

Author of last update: Melvin.boenninger