copZ

copZ
168

copper transport protein, metallochaperone

Locus
BSU_33510
Molecular weight
7.20 kDa
Isoelectric point
4.16
Protein length
69 aaSequenceBlast
Gene length
210 bpSequenceBlast
Function
resistance to copper
Product
copper transport protein, metallochaperone
Essential
no
Synonyms
copZ, yvgY
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2608 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,443,613  3,443,822
The protein
Catalyzed reaction/ biological activity
transfers Cu(I) to CopA PubMed
Domains
HMA domain (aa 3-69) (according to UniProt)
Cofactors
carries a tetranuclear Cu(I) cluster (as [Cu4(S-Cys)4(N-His)2] cluster) PubMed
Structure
2QIF (PDB)
O32221 (AlphaFold)
Localization
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
Genes
csoR-copZ-copA
Description
PubMed
Open in new tab

csoR→copA

2025-04-04 08:09:55

Jstuelk

95

eb86b49e4fa20367c75145f1a228f37db4b5da04

AAFF284B2BD1673523D4C48EA1D3231D7A156AFC

Genes
copZ-copA
Description
PubMed
Regulation
induced by copper (CsoR) PubMed
Regulatory mechanism
CsoR: repression, PubMed, in csoR regulon
Sigma factors
SigA: sigma factor, PubMed, in sigA regulon
Open in new tab

copZ→copA

2025-04-04 07:59:45

ghost

127

82e064a450e42e8934b8717c092adbe5ec47123b

C1EEB785789E5FED12C2A62EF4EB3404C7EFF35B

Biological materials
Mutant
BKE33510 (copZ::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATCAATTCCTCCTGTTT,  downstream forward: _UP4_TGATTCAAGGTATCGCGCCT
BKK33510 (copZ::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATCAATTCCTCCTGTTT,  downstream forward: _UP4_TGATTCAAGGTATCGCGCCT
Labs working on this gene/protein
John Helmann, Cornell University, USA Homepage
References
Reviews
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Original Publications
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18506FB74F6BB9278F22EB7DCDA3CF72575CC32A

Page visits: 4542

Time of last update: 2025-04-10 00:52:07

Author of last update: Melvin.boenninger